Multiple Antigenic Peptides (MAPs)
An alternative system to produce antibodies using peptide-conjugates is to use MAPs (Multiple Antigenic Peptides). In this case, the peptide chain grows on a 4 branching lysine core. Lysine has two amino groups and can be used to build up a large branching lysine complex.
In general, use the 4-branch MAP resin for peptides containing more than 15 amino acid residues and the 8-branch MAP resin for peptides shorter than 15 amino acids.
The desired epitope should be at the distal flexible end of the peptide. This approach produces a higher titer of anti-peptide antibodies, eliminating the presence of contaminant anti-carrier antibodies.
Structure of 4-branched MAP
Custom sythesis of peptides having in their sequence special amino acid derivates bearing stable isotopes (2H, 13C, 15N) is also available at Primm. Please submit your sequence and inquire for a customized quote. New Quotation
Metal Binding Peptides
Custom synthesis of peptide conjugates, in which a chelating agent (DOTA, DTPA, DTPAGlu, Phorphirins) is covalently linked to the peptide, is also available at Primm . These conjugates are able to give very stable complexes of many metals or with radioactive isotopes of metals currently in use in Nuclear Medicine (111In, 90Y,99mTc,177Lu, 68Ga). Please ask for a customized quote. New Quotation