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Research & Development
Yomics™
Different from "traditional"
proteomic approaches based
on protein isolation and mass
spectrometry characterization,
PRIMM's proteomic strategy
relies on protein identification
by
immune-chemistry analysis.
The availability of a "draft" of the
entire human genome sequence
allows the physical isolation of
most of the human genes by
Polymerase Chain Reaction
(PCR).
Once isolated, each gene is
expressed, the corresponding
recombinant protein is purified and
used to immunize mice
to obtain
specific polyclonal antibodies.
The availability of a library of
sera against a large panel
of
human proteins is the key feature
of the PRIMM technology.
In
fact, antibodies can be used
to visualize the corresponding
proteins, exploiting classical
immunochemistry techniques.
If such analysis is carried out
comparing protein expression
in tissues derived from healthy
and disease-carrying individuals,
disease-associated proteins can
be uncovered.
Antibody Libraries for Functional Proteomics |
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